Experimental and functional evaluation of wound-healing activity of hydrogel based on carboxymethylcellulose with biologically active substances from Pacific Ocean aquatic organisms in thermal burns

Authors

Keywords:

burn wound healing, hydrogels, carboxymethylcellulose, fucoidan

Abstract

Continuous improvement of local treatment of burn wounds and development of new wound dressings are inextricably linked with hydrogels from carboxymethylcellulose (CMC) and biologically active substances from Pacific Ocean aquatic organisms. The aim of the study is to obtain scientific information on the wound-healing activity of a hydrogel based on CMC and fucoidan on a burn wound model. Materials and methods. The experiment was conducted on 32 male white mice of the BALB/C line weighing 25±3 g, aged 8 weeks, which were modeled with a burn wound in the dorso-caudal region by contact and the wound-healing effect was monitored by planimetric method. Results. In the group treated with hydrogel with fucoidan, on the 7th day, a reliable increase in the index and rate of wound healing was recorded against the background of a decrease in its area, compared with the control group. In this case, proliferation was characterized by active growth of granulations with subsequent circular epithelization and gradual peeling of the scab as new tissue grows, which is the result of the replacement of granulation tissue with connective tissue and epithelization of the wound surface. Thus, during the functional assessment of the regenerative properties of a hydrogel based on CMC with fucoidan in mice with a thermal burn, the ability to significantly accelerate healing was revealed. 

Author Biographies

  • Anna А. Klimovich, Pacific Institute of Bioorganic Chemistry named after G.B. Elyakova FEB RAS

    Candidate of Biological Sciences, Researcher at the Laboratory of Molecular Pharmacology and Biomedicine

  • Ekaterina А. Chingizova, Pacific Institute of Bioorganic Chemistry named after G.B. Elyakova FEB RAS

    Candidate of Biological Sciences, Senior Researcher at the Laboratory of Biotesting and the Mechanism of Action of Biologically Active Substances

  • Evgeniy А. Pislyagin, Pacific Institute of Bioorganic Chemistry named after G.B. Elyakova FEB RAS

    Candidate of Biological Sciences, Senior Researcher at the Laboratory of Biotesting and the Mechanism of Action of Biologically Active Substances

  • Vladimir N. Kotelnikov, Far-Eastern branch of the State Research Testing Institute of Military Medicine; Far-Eastern Federal University

    Doctor of Medical Sciences, Professor, Head of the Far Eastern Branch of the State Research Testing Institute of Military Medicine; Professor of the Clinical Department School of Medicine and Life Sciences

  • Igor A. Shperling, State Research Testing Institute of Military Medicine

    Doctor of Medical Sciences, Professor, Deputy Head of the Research Testing Center

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Published

2025-06-11

Issue

Vol. 1 No. 2 (2025)

Section

PHYSIOLOGY

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Copyright (c) 2025 Анна Анатольевна Климович, Екатерина Александровна Чингизова, Евгений Александрович Пислягин, Владимир Николаевич Котельников, Игорь Алексеевич Шперлинг

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How to Cite

Experimental and functional evaluation of wound-healing activity of hydrogel based on carboxymethylcellulose with biologically active substances from Pacific Ocean aquatic organisms in thermal burns. (2025). Clinical and Fundamental Medicine, 1(2), 5-12. https://journals.dvfu.ru/clinfundmed/article/view/1704

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