Hydrogel wound coverings made of synthetic polymers: current status and immediate prospects

Authors

Keywords:

hydrogels, wound healing, carboxymethylcellulose, polyvinyl alcohol, wound coverings, synthetic polymers

Abstract

The purpose of the study is to summarize scientific data on hydrogel wound coverings consisting of synthetic polymers, using the example of the most practically applicable carboxymethylcellulose (CMC) and polyvinyl alcohol (PVA). For successful treatment of wounds, it is necessary to create a coating that can constantly “adapt” to the changes occurring in the wound. Hydrogels are promising substances for creating an “ideal” wound covering, due to a number of unique physicochemical properties in these hydrophilic macromolecular networks. These types of coverings have high strength and ductility, which allows them to fit tightly to the uneven edge of the wound and be firmly fixed, which reduces the risk of infection while maintaining optimal air exchange. Hydrogels made from CMC and PVA are capable of prolonging the action of biologically active substances introduced into them and are transparent, which makes it possible to control wound healing, and are also biocompatible and biodegradable. Inexpensive and widely available synthetic polymers CMC and PVA are a promising basis for creating hydrogel wound coverings.

Author Biographies

  • Ekaterina A. Chingizova, G.B. Elyakov Pacific Institute of Bioorganic Chemistry; Far-Eastern branch of the State Research Testing Institute of Military Medicine

    Candidate of Biological Sciences, Researcher at the Laboratory of Biotesting and the Mechanism of Action of Biologically Active Substances

  • Vladimir N. Kotelnikov, Far-Eastern branch of the State Research Testing Institute of Military Medicine; Far-Eastern Federal University

    Doctor of Medical Sciences, Professor, Head of the Far Eastern Branch of State Research and Testing Institute of Military Medicine; Professor of the Clinical Department, School of Medicine and Life Sciences

  • Igor A. Shperling, Far-Eastern branch of the State Research Testing Institute of Military Medicine

    Doctor of Medical Sciences, Professor, Deputy Head of the Research Testing Center

  • Boris I. Geltser, Far-Eastern Federal University

    Doctor of Medical Sciences, Professor, Corresponding Member RAS; Deputy Director for Science, School of Medicine and Life Sciences

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Published

2025-02-20

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Vol. 1 No. 1 (2025)

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PHYSIOLOGY

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Copyright (c) 2025 Владимир Николаевич Котельников, Екатерина Александровна Чингизова, Игорь Алексеевич Шперлинг, Борис Израилевич Гельцер

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Hydrogel wound coverings made of synthetic polymers: current status and immediate prospects. (2025). Clinical and Fundamental Medicine, 1(1), 5–15. https://journals.dvfu.ru/clinfundmed/article/view/1210

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