Verification of anaplastic thyroid carcinoma: a comprehensive analysis of the limitations of current methods

Authors

DOI:

https://doi.org/10.24866/3033-5485/2025-3/38-49

Keywords:

anaplastic thyroid carcinoma, immunohistochemistry, core needle biopsy, fine-needle aspiration biopsy, diagnosis, non-diagnostic specimen

Abstract

Anaplastic thyroid carcinoma is one of the most aggressive malignant neoplasms, characterized by an extremely poor prognosis and requiring prompt diagnostic verification to initiate an optimal therapeutic approach. The catastrophic prognosis is due to a unique combination of biological aggressiveness, resistance to therapy, and diagnostic challenges associated with the morphological heterogeneity of the tumor. The present study demonstrates significant limitations of conventional cytological diagnostic methods, including fine-needle aspiration biopsy, in the verification of this pathology, which are attributable to the characteristic morphological features of the tumor tissue. 

Author Biographies

  • Artur A. Mustafaev, Far Eastern Federal University

    2nd year Resident of the Specialty "Oncology"

  • Roman A. Goncharuk, Far Eastern Federal University

    Candidate of Medical Sciences, Director of the School of Medicine and Life Sciences, Surgeon, Oncologist

  • Regina A. Dumbrava, Primorsky Regional Oncology Dispensary

    Oncologist

  • Evgeniya V. Hamueva, Primorsky Regional Oncology Dispensary

    Head of the Pathology Department, Pathologist

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Published

2025-09-26

Issue

Vol. 1 No. 3 (2025)

Section

ONCOLOGY, RADIATION THERAPY

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Copyright (c) 2025 Артур Альбертович Мустафаев, Роман Анатольевич Гончарук, Регина Анатольевна Думбрава, Евгения Владимировна Хамуева

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How to Cite

Verification of anaplastic thyroid carcinoma: a comprehensive analysis of the limitations of current methods. (2025). Clinical and Fundamental Medicine, 1(3), 38-49. https://doi.org/10.24866/3033-5485/2025-3/38-49