Modern concepts about the role and representation of macrophages in various tissues of the body
Abstract
Macrophages have an essential role in the immune system, participating in the processes of inflammation, tissue regeneration and homeostasis maintenance. Modern studies focus on the plasticity and functional heterogeneity of macrophages, their interaction with microenvironment cells and their involvement in the pathogenesis of various diseases, including cancer, atherosclerosis and neurodegenerative disorders. The review systematizes data published over the past five years on the characteristics and additional properties of macrophages in various tissues, their role in the immune response and the possibilities of therapeutic modulation. The presented results highlight the prospects for using macrophages as targets for developing new approaches to treatment.
References
1. Федоров А.А., Ермак Н.А., Геращенко Т.С., Топольницкий Е.Б., Шефер Н.А., Родионов Е.О., Стахеева М.Н. Поляризация макрофагов: механизмы, маркеры и факторы индукции // Сибирский онкологический журнал. 2022. Т. 21, № 4. С. 124–136. DOI: https://doi.org/10.21294/1814-4861-2022-21-4-124-136 = Fedorov A.A., Ermak N.A., Gerashchenko T.S., Topolnitskii E.B., Shefer N.A., Rodionov E.O., Stakheyeva M.N. Polarization of macrophages: mechanisms, markers and factors of induction. Siberian Journal of Oncology, 2022, vol. 21, no. 4, pp. 124–136. (In Russ.). DOI: https://doi.org/10.21294/1814-4861-2022-21-4-124-136
2. Park M.D., Silvin A., Ginhoux F., Merad M. Macrophages in health and disease. Cell, 2022, vol. 185, no. 23, pp. 4259–4279. DOI: https://doi.org/10.1016/j.cell.2022.10.007
3. Жгулева А.С., Зементова М.С., Сельков С.А., Соколов Д.И. Макрофаги М1/М2: происхождение, фенотип, способы получения, взаимодействие с естественными киллерами и трофобластом // Медицинская иммунология. 2024. Т. 26, № 3. С. 425–448. DOI: https://doi.org/10.15789/1563-0625-MMO-2877 = Zhguleva A.S., Zementova M.S., Selkov S.A., Sokolov D.I. M1/M2 macrophages: origin, phenotype, methods of production, interaction with natural killer cells and trophoblast. Medical Immunology (Russia), 2024, vol. 26, no. 3, pp. 425–448. (In Russ.). DOI: https://doi.org/10.15789/1563-0625-MMO-2877
4. Юрова К.А., Хазиахматова О.Г., Малащенко В.В., Норкин И.К., Иванов П.А., Хлусов И.А., Шунькин Е.О., Тодосенко Н.М., Мелащенко Е.С., Литвинова Л.С. Клеточно-молекулярные аспекты воспаления, ангиогенеза и остеогенеза. Краткий обзор // Цитология. 2020. Т. 62, № 5. С. 305–315. DOI: https://doi.org/10.31857/S0041377120050090 = Yurova K.A., Khaziakhmatova O.G., Todosenko N.M., Litvinova L.S. The role of γC cytokines (Il-2, Il-7, and Il-15) in regulation of activation-induced cell death of memory T cells. Cell and Tissue Biology, 2020, vol. 14, no. 6, pp. 419–426. DOI: https://doi.org/10.1134/S1990519X20060115
5. Сахаров В.Н., Литвицкий П.Ф. Возможности управления процессом перепрограммирования фенотипа макрофагов // Сеченовский вестник. 2014. № 4. С. 89–96. = Sakharov V.N., Litvitsky P.F. Opportunities for management of macrophage phenotype reprogramming. Sechenov Medical Journal, 2014, no. 4, pp. 89–96.
6. Chen S., Saeed A.F.U.H., Liu Q., Jiang Q., Xu H., Xiao G.G., Rao L., Duo Y. Macrophages in immunoregulation and therapeutics. Signal Transduction and Targeted Therapy, 2023, vol. 8, art. 207. DOI: https://doi.org/10.1038/s41392-023-01452-1
7. Ковалева О.В., Подлесная П.А., Грачев А.Н. Цитотоксическая активность макрофагов и ее роль в патогенезе опухолей // Альманах клинической медицины. 2022. Т. 50. № 1. C. 13–20. DOI: https://doi.org/10.18786/2072-0505-2022-50-008 = Kovaleva O.V., Podlesnaya P.A., Gratchev A.N. Macrophage cytotoxic activity and its role in the tumor pathogenesis. Almanac of Clinical Medicine, 2022, vol. 50, no. 1, pp. 13–20. (In Russ.). DOI: https://doi.org/10.18786/2072-0505-2022-50-008
8. Susilawati T.N., Rahayuningtyas W., Pramana T.Y. Proinflammatory cytokines and its correlation with liver injury. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 2021, vol. 22, no. 3, pp. 210–216. DOI: https://doi.org/10.24871/2232021210-216
9. Wen Y., Lambrecht J., Ju C., Tacke F. Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities. Cellular & Molecular Immunology, 2021, vol. 18, pp. 45–56. DOI: https://doi.org/10.1038/s41423-020-00558-8
10. Wang C., Ma C., Gong L., Guo Y., Fu K., Zhang Y., Zhou H., Li Y. Macrophage polarization and its role in liver disease. Frontiers in Immunology, 2021, vol. 12, art. 803037. DOI: https://doi.org/10.3389/fimmu.2021.803037
11. Максимова А.А., Шевела Е.Я., Черных Е.Р. Роль макрофагов в патогенезе легочного фиброза // Иммунология. 2024. Т. 45, № 2. С. 235–244. DOI: https://doi.org/10.33029/1816-2134-2024-45-2-235-244 = Maksimova A.A., Shevela E.Ya., Chernykh E.R. The role of macrophages in the pathogenesis of pulmonary fibrosis. Immunologiya, 2024, vol. 45, no. 2, pp. 235–244. (In Russ.). DOI: https://doi.org/10.33029/1816-2134-2024-45-2-235-244
12. Зинина Е.П., Царенко С.В., Логунов Д.Ю., Тухватулин А.И., Бабаянц А.В., Аврамов А.А. Роль провоспалительных и противовоспалительных цитокинов при бактериальной пневмонии. Обзор литературы // Вестник интенсивной терапии имени А.И. Салтанова. 2021. № 1. С. 77–89. DOI: https://doi.org/10.21320/1818-474X-2021-1-77-89 = Zinina E.P., Tsarenko S.V., Logunov D.Y., Tukhvatulin A.I., Babayants A.V., Avramov А.А. The role of proinflammatory and anti-inflammatory cytokines in bacterial pneumonia. Review. Annals of Critical Care, 2021, no. 1, pp. 77–89. (In Russ.). DOI: https://doi.org/10.21320/1818-474X-2021-1-77-89
13. Буслаев В.Ю., Минин А.В., Катанахова М.В., Шабалдин А.В. Роль факторов иммунного ответа в развитии рака лёгкого у пациентов в зависимости от статуса курения (систематический обзор) // Фундаментальная и клиническая медицина. 2024. Т. 9, № 3. С. 86–97. DOI: https://doi.org/10.23946/2500-0764-2024-9-3-86-97 = Buslaev V.Yu., Minin A.V., Katanakhova M.V., Shabaldin A.V. Immune response, smoking, and lung cancer: a systematic review. Fundamental and Clinical Medicine, 2024, vol. 9, no. 3, pp. 86–97. (In Russ.). DOI: https://doi.org/10.23946/2500-0764-2024-9-3-86-97
14. Мироманов А.М., Гусев К.А., Старосельников А.Н., Миронова О.Б., Мироманова Н.А. Современные генетические и иммунологические аспекты патогенеза нарушения консолидации переломов (обзор литературы) // Acta Biomedica Scientifica. 2022. Т. 7. № 2. С. 49–64. DOI: https://doi.org/10.29413/ABS.2022-7.2.6 = Miromanov A.M., Gusev K.A., Staroselnikov A.N., Mironova O.B., Miromanova N.A. Modern genetic and immunological aspects of the pathogenesis of impaired consolidation of fractures (literature review). Acta Biomedica Scientifica, 2022, vol. 7, no. 2, pp. 49–64. (In Russ.). DOI: https://doi.org/10.29413/ABS.2022-7.2.6
15. Ширинский В.С., Ширинский И.В. Остеоиммунология: междисциплинарный подход к изучению взаимодействия клеток иммунной системы и костной ткани // Медицинская иммунология. 2022. Т. 24, № 5. С. 911–930. DOI: https://doi.org/10.15789/1563-0625-OAI-1521 = Shirinsky V.S., Shirinsky I.V. Osteoimmunology: an interdisciplinary approach to studying the relationships between immune and bone cells. Medical Immunology, 2022, vol. 24, no. 5, pp. 911–930. (In Russ.). DOI: https://doi.org/10.15789/1563-0625-OAI-1521
16. McDonald M.M., Kim A.S., Mulholland B.S., Rauner M. New insights into osteoclast biology. JBMR Plus, 2021, vol. 5, no. 9, art. e10539. DOI: https://doi.org/10.1002/jbm4.10539
17. Khan N.M., Clifton K.B., Lorenzo J., Hansen M.F., Drissi H. Comparative transcriptomic analysis identifies distinct molecular signatures and regulatory networks of chondroclasts and osteoclasts. Arthritis Research & Therapy, 2020, vol. 22, art. 168. DOI: https://doi.org/10.1186/s13075-020-02259-z
18. McClure S.F., McClure J. Aspects of the glycome of endochondral ossification. BioRxiv, 2022, art. 2022.05.12.491629. DOI: https://doi.org/10.1101/2022.05.12.491629
19. Hyc A., Moskalewski S., Osiecka-Iwan A. Growth factors in the initial stage of bone formation, analysis of their expression in chondrocytes from epiphyseal cartilage of rat costochondral junction. Folia Histochemica et Cytobiologica, 2021, vol. 59, no. 3, pp. 178–186. DOI: https://doi.org/10.5603/fhc.a2021.0017
20. Yan B., Liu N., Li J., Li J., Zhu W., Kuang Y., Chen X., Peng C. The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis. Journal of Cellular and Molecular Medicine, 2020, vol. 24, no. 20, pp. 11646–11655. DOI: https://doi.org/10.1111/jcmm.15834
21. Neagu M., Constantin C., Jugulete G., Cauni V., Dubrac S., Szöllősi A.G., Zurac S. Langerhans cells – revising their role in skin pathologies. Journal of Personalized Medicine, 2022, vol. 12, no. 12, art. 2072. DOI: https://doi.org/10.3390/jpm12122072
22. Wang Z.-C., Hu Y.-Y., Shen X.Z., Tan W.-Q. Absence of Langerhans cells resulted in over-influx of neutrophils and increased bacterial burden in skin wounds. Cell Death & Disease, 2024, vol. 15, art. 760. DOI: https://doi.org/10.1038/s41419-024-07143-1
23. Klei T.R.L., Dalimot J., Nota B., Veldthuis M., Mul F.P.J., Rademakers T., Hoogenboezem M., Nagelkerke S.Q., van IJcken W.F.J., Oole E., Svendsen P., Moestrup S.K., van Alphen F.P.J., Meijer A.B., Kuijpers T.W., van Zwieten R., van Bruggen R. Hemolysis in the spleen drives erythrocyte turnover. Blood, 2020, vol. 136, no. 14, pp. 1579–1589. DOI: https://doi.org/10.1182/blood.2020005351
24. Norris P.A.A., Segel G.B., Burack W.R., Sachs U.J., Lissenberg-Thunnissen S.N., Vidarsson G., Bayat B., Cserti-Gazdewich C.M., Callum J., Lin Y., Branch D., Kapur R., Semple J.W., Lazarus A.H. FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia. Haematologica, 2021, vol. 106, no. 1, pp. 250–254. DOI: https://doi.org/10.3324/haematol.2020.248385
25. Chen Y., Xiang J., Qian F., Diwakar B.T., Ruan B., Hao S., Prabhu K.S., Paulson R.F. Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation. Blood, 2020, vol. 136, no. 2, pp. 235–246. DOI: https://doi.org/10.1182/blood.2019003480
26. Fakonti G., Pantazi P., Bokun V., Holder B, Placental macrophage (Hofbauer cell) responses to infection during pregnancy: A systematic scoping review. Frontiers in Immunology, 2022, vol. 12, art. 756035. DOI: https://doi.org/10.3389/fimmu.2021.756035
27. Bezemer R.E., Faas M.M., van Goor H., Gordijn S.J., Prins J.R. Decidual macrophages and Hofbauer cells in fetal growth restriction. Frontiers in Immunology, 2024, vol. 15, art. 1379537. DOI: https://doi.org/10.3389/fimmu.2024.1379537
28. Thomas J.R., Appios A., Zhao X., Dutkiewicz R., Donde M., Lee C.Y.C., Naidu P., Lee C., Cerveira J., Liu B., Ginhoux F., Burton G., Hamilton R.S., Moffett A., Sharkey A., McGovern N. Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells. Journal of Experimental Medicine, 2021, vol. 218, no. 1, e20200891. DOI: https://doi.org/10.1084/jem.20200891
29. Mercnik M.H., Wadsack C., Schliefsteiner C. Unlocking the secrets of Hofbauer cells in placental (patho-) physiology: Isolation and quality assessment in human term placenta. Placenta, 2024, Jul 10. DOI: https://doi.org/10.1016/j.placenta.2024.07.004
30. Azari S., Johnson LJ., Webb A., Kozlowski S.M., Zhang X., Rood K., Amer A., Seveau S. Hofbauer cells spread listeria monocytogenes among placental cells and undergo pro-inflammatory reprogramming while retaining production of tolerogenic factors. MBio, 2021, vol. 12, no. 4, art. 10.1128/mbio.01849-21. DOI: https://doi.org/10.1128/mbio.01849-21
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